Nationals bring back manager Johnson for 2013

{ttle}

{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"95735613","sec":""}}},{"id": "hcm-carousel-62506535", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-62506535", "track_item_selected":1,"tracking":{
"spaceid" : "95735613",
"events" : {
"click" : {
"any" : {
"yui-carousel-prev" : {
"node" : "a",
"data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" },
"bubbles" : true,
"test": function(params){
var carousel = params.obj.getCarousel();
var pages = carousel._pages;

// if same page, don't beacon
if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false;

// keep track of current position within this closure
carousel._ult_current_page = pages.cur;

return true;
}
},
"yui-carousel-next" : {
"node" : "a",
"data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" },
"bubbles" : true,
"test": function(params){
var carousel = params.obj.getCarousel();
var pages = carousel._pages;

// no more pages, don't beacon again
// if same page, don't beacon
if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false;

// keep track of current position within this closure
carousel._ult_current_page = pages.cur;
return true;
}
}
}
}
}
}
}));
});
Y.later(10, this, function() {(function() {
try{
if (Math.floor(Math.random()*10) == 1) {
var loc = window.location,
decoded = decodeURI(loc.pathname),
encoded = encodeURI(decoded),
uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1",
xmlhttp;

if (window.XMLHttpRequest)
xmlhttp = new XMLHttpRequest();
else
xmlhttp = new ActiveXObject("Microsoft.XMLHTTP");

xmlhttp.open("GET",uri,true);
xmlhttp.send();
}
}catch(e){}
})();
});
Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "95735613" ,"customFields" : { "12" : "classic", "13" : "story" }';
Y.Media.YWA.init(Y.namespace("Media").ywaSettings);
});
Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;}
});
});
});

Read More..

Malaria vaccine a letdown for infants

LONDON (AP) — An experimental malaria vaccine once thought promising is turning out to be a disappointment, with a new study showing it is only about 30 percent effective at protecting infants from the killer disease.

That is a significant drop from a study last year done in slightly older children, which suggested the vaccine cut the malaria risk by about half — though that is still far below the protection provided from most vaccines. According to details released on Friday, the three-shot regimen reduced malaria cases by about 30 percent in infants aged 6 to 12 weeks, the target age for immunization.

Dr. Jennifer Cohn, a medical coordinator at Doctors Without Borders, described the vaccine's protection levels as "unacceptably low." She was not linked to the study.

Scientists have been working for decades to develop a malaria vaccine, a complicated endeavor since the disease is caused by five different species of parasites. There has never been an effective vaccine against a parasite. Worldwide, there are several dozen malaria vaccine candidates being researched.

In 2006, a group of experts led by the World Health Organization said a malaria vaccine should cut the risk of severe disease and death by at least half and should last longer than one year. Malaria is spread by mosquitoes and kills more than 650,000 people every year, mostly young children and pregnant women in Africa. Without a vaccine, officials have focused on distributing insecticide-treated bed nets, spraying homes with pesticides and ensuring access to good medicines.

In the new study, scientists found babies who got three doses of the vaccine had about 30 percent fewer cases of malaria than those who didn't get immunized. The research included more than 6,500 infants in Africa. Experts also found the vaccine reduced the amount of severe malaria by about 26 percent, up to 14 months after the babies were immunized.

Scientists said they needed to analyze the data further to understand why the vaccine may be working differently in different regions. For example, babies born in areas with high levels of malaria might inherit some antibodies from their mothers which could interfere with any vaccination.

"Maybe we should be thinking of a first-generation vaccine that is targeted only for certain children," said Dr. Salim Abdulla of the Ifakara Health Institute in Tanzania, one of the study investigators.

Results were presented at a conference in South Africa on Friday and released online by the New England Journal of Medicine. The study is scheduled to continue until 2014 and is being paid for by GlaxoSmithKline and the PATH Malaria Vaccine Initiative.

"The results look bad now, but they will probably be worse later," said Adrian Hill of Oxford University, who is developing a competing malaria vaccine. He noted the study showed the Glaxo vaccine lost its potency after several months. Hill said the vaccine might be a hard sell, compared to other vaccines like those for meningitis and pneumococcal disease — which are both effective and cheap.

"If it turns out to have a clear 30 percent efficacy, it is probably not worth it to implement this in Africa on a large scale," said Genton Blaise, a malaria expert at the Swiss Tropical and Public Health Institute in Basel, who also sits on a WHO advisory board.

Eleanor Riley of the London School of Hygiene and Tropical Medicine, said the vaccine might be useful if used together with other strategies, like bed nets. She was involved in an earlier study of the vaccine and had hoped for better results. "We're all a bit frustrated that it has proven so hard to make a malaria vaccine," she said. "The question is how much money are the funders willing to keep throwing at it."

Glaxo first developed the vaccine in 1987 and has invested $300 million in it so far.

WHO said it couldn't comment on the incomplete results and would wait until the trial was finished before drawing any conclusions.

Read More..

AP source: Justin Bieber and Selena Gomez break up

NEW YORK (AP) — A source confirms to The Associated Press that Justin Bieber is no longer Selena Gomez's "Boyfriend."

The source is not authorized to discuss the split with the press and spoke on condition of anonymity.

The breakup apparently happened last week. Distance and their busy schedules were cited as factors.

Eighteen-year-old Bieber is touring to promote his latest album, "Believe," which contains the hit "Boyfriend." Twenty-year-old Gomez is filming a "Wizards of Waverly Place" reunion for the Disney Channel.

The pair made their relationship public in February 2011.

E! News was the first to report the split.

Bieber seems to be doing OK, at least publicly. On the red carpet of Wednesday's Victoria's Secret fashion show he said, "I'd rather be here than anywhere in the world."

___

Online:

http://www.justinbiebermusic.com/

http://www.selenagomez.com/

Read More..

Retailers plan earlier start to Black Friday

Cierra Hobson is a die-hard Black Friday shopper.

Every year she queues in front of one of her favorite stores, where she waits, in her pajamas, in hopes of bagging a good deal.

This year, Hobson and other deal-seekers will find some twists on the post-Thanksgiving Day ritual: coupons delivered via mobile phones and deeper discounts, maneuvers designed to make shopping easier for consumers and to set retailers on a strong start to the biggest shopping period of the year. But perhaps the biggest change will be an earlier start to the holiday rush.

Black Friday historically launched the day after Thanksgiving. But in recent years, stores have opened at 4 a.m., then midnight. Last year, retailers created a stir by opening at 10 p.m. Thursday. This year, Sears and Wal-Mart announced plans to open at 8 p.m.

"The name of the game this holiday season is who can do it best," said National Retail Federation spokeswoman Kathy Grannis.

"When (early openings) started in 2009, things were a little bit worse off in terms of consumer confidence," Grannis added. "At that point it was very necessary for retailers to get out there before anybody else, and that literally meant before midnight."

This year, holiday spending is expected to rise 4.1 percent, according to the retail federation. Last year, more than 24 percent of Black Friday shoppers were out before midnight and nearly 39 percent of shoppers were in the stores before 5 a.m.

Wal-Mart plans to greet shoppers with the likes of $89 Wii consoles and a $38 Blu-ray player. At Sears, there will be perks on sale items for members of its shopper loyalty program.

Both retailers are touting in-store pickup, allowing customers to buy items online and pick them up at the store, avoiding checkout lines.

The Disney Store plans to begin offering Black Friday deals on the Monday before Thanksgiving, though Disney stores will open at midnight in some markets and 5 a.m. in others. Ads leaked to Internet deal sites say Target stores will open at 9 p.m. on Thanksgiving.

Last year, Wal-Mart recorded its most customer traffic at 10 p.m. on Thanksgiving night, said spokesman Steven Restivo, adding that the retailer relied on focus groups, online surveys and other feedback to help it decide to open two hours earlier this year. "Our customers told us they loved our Thanksgiving event last year and wanted it again."

At Sears, staying open 26 consecutive hours through Black Friday gives its customers the flexibility they want and makes good business sense, said spokesman Brian Hanover.

"There's a segment of Sears customers who want that thrill of holiday shopping to start as soon as their Thanksgiving dinner ends," he said. "Traditionalists," he added, can wait for door busters at 4 a.m.

Despite discounts that often go beyond 50 percent, stores still make money on the sales, retail experts say. That's because shoppers in physical stores tend to spend more than they planned, said Sanjay Dhar, professor of marketing at the University of Chicago Booth School of Business.

In the store, "you end up making purchases that aren't as marked down, in addition to the door-buster deals," he said.

Opening earlier and staggering door-buster deals is not only a good way to make money, but it's also necessary for crowd control, retail watchers say. In 2008, a store employee was trampled to death in a Black Friday door-buster stampede at a Long Island, N.Y., Wal-Mart.

Hobson said she doesn't plan to start shopping Thanksgiving night, but she said she'll be up before dawn to catch sales at Express, a clothing store.

"Just knowing that everybody is doing the same thing I'm doing on the same day feels like the beginning of Christmas," she said.

Others worry that super-early openings could backfire.

Sheri Petras, CEO of CFI Group, a Michigan-based consultancy, said store employees grumpy from having to leave their Thanksgiving festivities will take out their anger on customers.

"Consumers will not spend as much with cranky employees," she said.

Some employees at Wal-Mart, Sears and Target say they'd like the day off.

Change.org, an activist website, said Friday that more than 20 new petitions were submitted by employees and consumers asking retailers to reconsider their Thanksgiving evening openings.

It's the second year the website has administered petitions calling for retailers to stick to traditional Black Friday openings.

In a statement distributed by OUR Walmart, a labor rights group, Wal-Mart employee Mary Pat Tifft, of Wisconsin, said she would be "devastated" if she had to work on Thanksgiving, because she is expecting her son home from Afghanistan for the holiday.

"This early opening is one more example of Walmart's disconnect with the workers who keep its stores running and disregard for all of our families. As the largest employer in the country, Walmart could be setting a standard for businesses to value families, but instead, this is one more Walmart policy that hurts the families of workers at its stores," she said.

crshropshire@tribune.com

Twitter @corilyns

Read More..

Cook County OKs budget with $1-a-pack cigarette tax hike

A budget that includes higher or new taxes on cigarettes, gambling and guns is expected to sail through the Cook County Commission Friday.

The cost of buying cigarettes and guns in Cook County will rise next year after commissioners today voted 16-1 to approve County Board President Toni Preckwinkle's $2.95 billion budget.

In addition to the $1-per-pack increase on a pack of smokes and a new $25 per-gun tax on firearm purchases, the board also enacted a 1.25 percent use tax on large out-of-county purchases, with an exemption on the first $3,500 spent. There’s also a $1,000-per-year tax on slot machines and a $200-per-year tax on video gambling terminals.

The cigarette tax increases March 1, while the use tax and gun tax are effective April 1. The gambling machine tax won’t be implemented until June 1, giving the Illinois General Assembly time to offer up an alternative way to share gambling revenue with the county if it so chooses.

All those taxes, and some modest fee increases for permits and morgue documents, is expected to raise $41.7 million.

“I think the revenue increases are small, they’re targeted and largely they’re avoidable, if you so choose, to residents of the county,” said Commissioner Bridget Gainer, D-Chicago, as she voted in favor of the document.

Preckwinkle’s budget also kills off the last quarter-cent of the penny-on-the-dollar sales tax increase enacted under Preckwinkle’s predecessor, Todd Stroger, which will inflict an $86 million hit on the county’s bottom line. The county portion of the sales tax will drop to .75 percent on Jan. 1.

The only “no” vote came from Commissioner William Beavers, D-Chicago, who was Stroger’s floor leader and often has butted heads with Preckwinkle and Finance Committee Chairman John Daley, D-Chicago. All four Republicans on the 17-member board voted in favor of the budget, after lauding Preckwinkle’s bipartisan approach and cuts in spending.

Preckwinkle has defended the new cigarette and gun taxes by saying they will defray the costs to the county’s criminal justice and public health systems — which account for nearly three fourths of annual county spending — caused by smoking and guns by people who resell them to criminals for profit. The higher cigarette tax also could deter young people from starting the harmful habit, she said.

The use tax, which is expected to mostly affect businesses, is designed to encourage in-county purchases, Preckwinkle said.

The biggest chunk of new revenue will come from the cigarette tax, which follows a recent state increase of $1 per pack that went into effect June 24. County officials expect its increase to raise $25.6 million next year, saying they have accounted for folks who will leave the county to buy cigarettes or quit smoking.

Some commissioners, though, have questioned the long-term reliability of the cigarette tax increase, which will boost the overall taxes on a pack of smokes in Chicago to $6.67 — making it just 19 cents shy of New York City’s nation-leading $6.86.

When the county last raised the cigarette tax by $1 per pack in 2006, collections initially shot up by $46.5 million, county records show. But three years later, in 2009, the county collected $20.4 million less than it had in 2005.

The 1.25 percent “buy-local tax” on out-of-county purchases, expected to bring in $13.8 million, is on shaky legal ground, according to a Taxpayers’ Federation of Illinois analysis. Preckwinkle’s aides said they believe the law will withstand any legal challenge.

Preckwinkle’s budget was aided when the federal government recently granted the county Health and Hospitals System a waiver that will allow the early enrollment of 115,000 more patients in Medicaid that otherwise wouldn’t pay for county health care. That is expected to net $99 million for the public health system.

One initiative included in the budget is a $2 million fund to make grants to groups that combat gun violence and set up a gun court.

Another is setting aside $5 million to upgrade roads and sewers in unincorporated areas to make them more attractive for annexation to neighboring suburbs. Preckwinkle aims to eliminate unincorporated areas, which put stress on the county’s budget, within the next decade.

She’s also continuing efforts to reduce the population at the Juvenile Temporary Detention Center, where it costs $600 a day to house and educate young people accused of crimes, by finding alternatives to get them treatment and guidance.

And she’s making more efforts to reduce the jail population, where it costs $143 a day to detain inmates, by taking steps to get more people accused of non-violent crimes released on bond while they await trial.

hdardick@tribune.com
Twitter @ReporterHal

Read More..

Exclusive: Google Ventures beefs up fund size to $300 million a year

SAN FRANCISCO (Reuters) - Google will increase the cash it allocates to its venture-capital arm to up to $300 million a year from $200 million, catapulting Google Ventures into the top echelon of corporate venture-capital funds.

Access to that sizeable checkbook means Google Ventures will be able to invest in more later-stage financing rounds, which tend to be in the tens of millions of dollars or more per investor.

It puts the firm on the same footing as more established corporate venture funds such as Intel's Intel Capital, which typically invests $300-$500 million a year.

"It puts a lot more wood behind the arrow if we need it," said Bill Maris, managing partner of Google Ventures.

Part of the rationale behind the increase is that Google Ventures is a relatively young firm, founded in 2009. Some of the companies it backed two or three years ago are now at later stages, potentially requiring larger cash infusions to grow further.

Google Ventures has taken an eclectic approach, investing in a broad spectrum of companies ranging from medicine to clean power to coupon companies.

Every year, it typically funds 40-50 "seed-stage" deals where it invests $250,000 or less in a company, and perhaps around 15 deals where it invests up to $10 million, Maris said. It aims to complete one or two deals annually in the $20-$50 million range, Maris said.

LACKING SUPERSTARS

Some of its investments include Nest, a smart-thermostat company; Foundation Medicine, which applies genomic analysis to cancer care; Relay Rides, a carsharing service; and smart-grid company Silver Spring Networks. Last year, its portfolio company HomeAway raised $216 million in an initial public offering.

Still, Google Ventures lacks superstar companies such as microblogging service Twitter or online bulletin-board company Pinterest. The firm's recent hiring of high-profile entrepreneur Kevin Rose as a partner could help attract higher-profile deals.

Soon it could have even more cash to play around with. "Larry has repeatedly asked me: 'What do you think you could do with a billion a year?'" said Maris, referring to Google chief executive Larry Page.

(Editing by Muralikumar Anantharaman)

Read More..

NHL labor talks under way for 4th straight day

NEW YORK (AP) — NHL owners and players face lots of work to save the hockey season. Whether they are moving closer after a week of talking remains to be seen.

The league and the players' association met Friday for the fourth straight day and fifth time in seven days, trying to reach an agreement to end the lockout. A union spokesman said there will be multiple meetings during the day to discuss collective bargaining matters.

The sides got an earlier start Friday than in previous days, perhaps recognizing the urgency on the 55th day of the lockout. The league has already called off 327 regular-season games, including the New Year's Day Winter Classic in Michigan, and said a full season won't be played.

If there is no deal soon, the NHL could lose a full season to a lockout for the second time in seven years.

NHL Commissioner Gary Bettman and players' association executive director Donald Fehr spoke publicly Thursday night after talks ended. Neither provided details on what was discussed or if progress was made. The one encouraging sign is that the sides continue to talk.

"I am not going to characterize it except to say, as I have before, that it's always better when you're meeting than when you're not," Fehr said Thursday night after the sides negotiated for more than five hours at the law offices of Proskauer Rose, the Manhattan firm of NHL lead counsel Bob Batterman.

It wasn't clear if the NHL responded favorably to a pair of offers the league received from the union Wednesday or if it made counterproposals Thursday. Both sides held internal meetings to review developments and prepare for Friday's discussions.

"I am not going to discuss the negotiations or the substance of what we're talking about," Bettman said Thursday on a wind-blown street corner. "I really don't think that would be helpful to the process.

"We have work to do, and my hope is that we can achieve the goal of getting a long-term, fair agreement in place as quickly as possible so we can play hockey."

The atmosphere was positive enough that Fehr didn't rule out the possibility that talks could stretch into the weekend, too.

But even if an agreement is reached soon, it isn't clear if any of this season's games that have been called off through Nov. 30 can be rescheduled. The NHL has said a full 82-game season won't be played.

"Every day that passes, I think, is critical for the game and for our fans," Bettman said.

During a second consecutive day of marathon negotiations Wednesday, the players' association made an offer on revenue sharing in which richer teams would help out poorer organizations, and another proposal regarding the "make-whole" provision that would guarantee full payment of all existing multiyear player contracts.

"There have been discussions over a wide range of topics. ... I am not going to comment on the substance of the discussions," Fehr said from the same spot on the street where Bettman talked.

Along with a handful of team owners, eight players attended Wednesday's talks, five fewer than Tuesday. Pittsburgh Penguins captain Sidney Crosby and others left New York to try to avoid the impending snowstorm that hit the area, the union said. On Thursday, seven players were in attendance, according to the NHLPA, and at least three owners.

The lockout began Sept. 16 after the collective bargaining agreement expired, and both sides rejected proposals Oct. 18. The belief is that the players' association has agreed to a 50-50 split of hockey-related revenues, but that division wouldn't kick in until the third year of the deal.

"Collective bargaining is a process, and it has peaks and valleys and ebbs and flows," Bettman said. "It is very tough to handicap."

Revenue sharing and the make-whole provision are major hurdles. Both sides have made proposals that included a 50-50 split of hockey-related revenues. The NHL has moved toward the players' side in the "make-whole" provision and whose share of the economic pie that money will come from.

Along with the split of hockey-related revenue and other core economic issues, contract lengths, arbitration and free agency also must be agreed upon.

The union accepted a salary cap in the previous labor pact, which wasn't reached until after the entire 2004-05 season was canceled because of a lockout. The union doesn't want to absorb the majority of concessions this time after the NHL had record revenue that exceeded $3 billion last season.

Read More..

On Twitter, pope to get different type of followers

VATICAN CITY (Reuters) – Pope Benedict already has 1.2 billion “followers” in the standard sense of the word but he soon will have another type when he enters what for any 85 year old is the brave new world of Twitter.

Vatican officials say the pontiff, who is known not to love computers and still writes most of his speeches by hand, will have his own handle by the end of the year.

“It will be an officially verified channel,” said a Vatican official.

Primarily the tweets will come from the contents of his weekly general audience, Sunday blessings and homilies on major Church holidays. They will also include reaction to major world events, such as natural disasters.

The leader of the world’s 1.2 billion or so Roman Catholics will not, of course, write the tweets himself, but he will sign off on them before they are sent in his name.

But even divine intervention might not help squeeze the gist of a papal encyclical, which can run to more than 140 pages, into 140 characters.

Those tweets will probably be limited to a link to a url with the entire document.

The papal handle has not yet been disclosed but it is widely expected to be @BenedictusPPXVI, his name and title in Latin.

The pope has given a qualified blessing to social networking.

In a document issued last year, he said the possibilities of new media and social networks offered “a great opportunity”, but warned of the risks of depersonalisation, alienation, self-indulgence, and the dangers of having more virtual friends than real ones.

In 2009, a new Vatican website, www.pope2you.net, went live, offering an application called “The pope meets you on Facebook”, and another allowing the faithful to see the pontiff’s speeches and messages on their iPhones or iPods.

The Vatican famously got egg on its face in 2009 when it was forced to admit that, if it had surfed the web more, it might have known that a traditionalist bishop whose excommunication was lifted had for years been a Holocaust denier.

(Reporting By Philip Pullella; editing by Mike Collett-White)

Celebrity News Headlines – Yahoo! News

Read More..

Malaria vaccine a letdown for infants

LONDON (AP) — An experimental malaria vaccine once thought promising is turning out to be a disappointment, with a new study showing it is only about 30 percent effective at protecting infants from the killer disease.

That is a significant drop from a study last year done in slightly older children, which suggested the vaccine cut the malaria risk by about half — though that is still far below the protection provided from most vaccines. According to details released on Friday, the three-shot regimen reduced malaria cases by about 30 percent in infants aged 6 to 12 weeks, the target age for immunization.

Dr. Jennifer Cohn, a medical coordinator at Doctors Without Borders, described the vaccine's protection levels as "unacceptably low." She was not linked to the study.

Scientists have been working for decades to develop a malaria vaccine, a complicated endeavor since the disease is caused by five different species of parasites. There has never been an effective vaccine against a parasite. Worldwide, there are several dozen malaria vaccine candidates being researched.

In 2006, a group of experts led by the World Health Organization said a malaria vaccine should cut the risk of severe disease and death by at least half and should last longer than one year. Malaria is spread by mosquitoes and kills more than 650,000 people every year, mostly young children and pregnant women in Africa. Without a vaccine, officials have focused on distributing insecticide-treated bed nets, spraying homes with pesticides and ensuring access to good medicines.

In the new study, scientists found babies who got three doses of the vaccine had about 30 percent fewer cases of malaria than those who didn't get immunized. The research included more than 6,500 infants in Africa. Experts also found the vaccine reduced the amount of severe malaria by about 26 percent, up to 14 months after the babies were immunized.

Scientists said they needed to analyze the data further to understand why the vaccine may be working differently in different regions. For example, babies born in areas with high levels of malaria might inherit some antibodies from their mothers which could interfere with any vaccination.

"Maybe we should be thinking of a first-generation vaccine that is targeted only for certain children," said Dr. Salim Abdulla of the Ifakara Health Institute in Tanzania, one of the study investigators.

Results were presented at a conference in South Africa on Friday and released online by the New England Journal of Medicine. The study is scheduled to continue until 2014 and is being paid for by GlaxoSmithKline and the PATH Malaria Vaccine Initiative.

"The results look bad now, but they will probably be worse later," said Adrian Hill of Oxford University, who is developing a competing malaria vaccine. He noted the study showed the Glaxo vaccine lost its potency after several months. Hill said the vaccine might be a hard sell, compared to other vaccines like those for meningitis and pneumococcal disease — which are both effective and cheap.

"If it turns out to have a clear 30 percent efficacy, it is probably not worth it to implement this in Africa on a large scale," said Genton Blaise, a malaria expert at the Swiss Tropical and Public Health Institute in Basel, who also sits on a WHO advisory board.

Eleanor Riley of the London School of Hygiene and Tropical Medicine, said the vaccine might be useful if used together with other strategies, like bed nets. She was involved in an earlier study of the vaccine and had hoped for better results. "We're all a bit frustrated that it has proven so hard to make a malaria vaccine," she said. "The question is how much money are the funders willing to keep throwing at it."

Glaxo first developed the vaccine in 1987 and has invested $300 million in it so far.

WHO said it couldn't comment on the incomplete results and would wait until the trial was finished before drawing any conclusions.

Read More..

Obama, Palin and Jobs join Bartlett's club

NEW YPRK (AP) — So much has changed since we last heard from "Bartlett's Familiar Quotations," a decade ago.

Barack Obama was a state legislator. Sarah Palin was mayor of Wasilla. Steve Jobs had just introduced a portable music player called the iPod.

And digital books were a relic from the dot-com bubble.

The 18th edition of the venerable reference work has just been released, the first for the electronic age and a chance to take in some of the new faces, events and catchphrases of the past 10 years. General editor Geoffrey O'Brien says he has expanded upon the trend set by his predecessor, Justin Kaplan, of incorporating popular culture into an anthology once known for classical citations. Shakespeare and the Bible still reign, but room also has been made for Madonna and Michael Moore, Justin Timberlake and Jon Stewart.

"I also added a great many quotes that originated in other languages. So I would say the new edition has a more international scope," says O'Brien, an author and critic and editor in chief of the Library of America, which publishes hardcover volumes of canonical American authors.

Little, Brown and Company hopes the new Bartlett's will appeal both as an old-fashioned coffee table hardcover, some 1,400 pages, and as an ultra-portable digital reference guide. Instead of releasing an e-book edition, the publisher has developed an app that does not simply replicate the printed book, but makes it ideal for digital devices and easy to share on Facebook or Twitter.

Dozens of employees spent months working on the app, according to Brian Singh, mobile analyst for Little, Brown's parent company, Hachette Book Group. Some 20,000 quotations were categorized so those looking for a quick quote — say a love poem for a wedding speech — could simply search the word "love." The app costs $3.95 and does not include any extra material, but it does have a digital feature, Quoto, which allows users to take a favorite citation, set it against a backdrop of choice and post it online.

For the hardcover, O'Brien said he removed some old poetry and forgotten phrases to make room for about 2,500 new quotes, including several from the Iraq War. Among them are President George W. Bush's call to "Bring 'em on" in response to possible uprisings from insurgents and his declaration that he was the "the decider." The Dixie Chicks' Natalie Maines is mentioned for her on-stage remark that she was "ashamed" Bush was from Texas, as is Moore's Academy Award acceptance speech when he criticized the war and called Bush a "fictitious president."

Seven Obama quotations are listed, from his campaign slogan "Yes, we can!" to his announcement that U.S. special forces had killed Osama bin Laden. Palin's entry includes the quip from her speech at the 2008 Republican convention that the difference between a hockey mom and a pit bull was "lipstick." Job's dying words, "Wow, oh wow," are among four citations for the late Apple CEO, including a 1987 comment that "It's more fun to be a pirate than to join the Navy."

Others in Bartlett's for the first time: Christopher Hitchens ("Seek out argument and disputation for their own sake"); David Foster Wallace ("Make no mistake: irony tyrannizes us"), Stewart (his nightly signoff, "Here it is ... your moment of Zen"), Timberlake (his apology for Janet Jackson's "wardrobe malfunction" during the 2004 Super Bowl halftime show).

Barlett's is home to polished aphorisms and unintentional history: Bill Clinton's "I did not have sex with that woman, Monica Lewinsky"; Oscar winner's Sally Field's cry that "You like me!"; Obama's comments at a private fundraiser that some rural residents "cling to guns or religion." Some quotes originate from tragedy: Rodney King's plea, "Can we all get along?", as Los Angeles burned during the 1992 riots; Flight 93 passenger Todd Beamer calling out "Let's roll" as he led an uprising against Sept. 11, 2011 hijackers.

The credentials for Bartlett's are admittedly arbitrary: Space concerns, individual tastes and the uncertain definition of the word "familiar" make the book an invaluable excuse for an argument.

Larry David is in, but not Aaron Sorkin; P.J. O'Rourke, not Maureen Dowd; Jerry Seinfeld and Steve Martin, not George Carlin or Richard Pryor. The many expressions coined on "Saturday Night Live," from "Talk amongst yourselves" to "Well, excuuuuuse me!" were not mentioned. Among novelists, Richard Powers is in, but not Jonathan Franzen; Colson Whitehead, not Michael Chabon.

"I am sure that twelve different well-informed people would come up with twelve different lists of people (and more importantly of specific quotations) left out, and I am sure some of these will be strong candidates for inclusion in the next edition," O'Brien said.

Among songwriting entries, excerpts appear from Lou Reed's lyrics for "All Tomorrow's Parties" and "Heroin," but not from the more famous "Walk On the Wild Side." The Beach Boys' "Carolina, No" gets a mention, but not such anthems as "Surfin' U.S.A." and "Good Vibrations." Kurt Cobain's entry omits "Smells Like Teen Spirit" in favor of "Stay Away" and "Serve the Servants."

For movies, two quotes are included from Robert Towne's "Chinatown" screenplay, but not the immortal closing line, "Forget it Jake, it's Chinatown." One of just two entries for Nora Ephron is "I'll have what she's having," the joke from "When Harry Met Sally ..." that is widely credited to Billy Crystal. Among the favorites left out: "Well, nobody's perfect," the kicker from "Some Like it Hot"; Arnold Schwarzenegger's "Terminator" catchphrase "I'll be back"; the courtroom explosion "You can't handle the truth!" from "A Few Good Men."

"Certain lines strike me as 'familiar for being familiar' — 'You can't handle the truth' being one of them, as I can see little originality or singularity in it," O'Brien said. "The price of compactness is a certain amount of arbitrary exclusion."

Read More..